لیست مقالات ISI

مقاله اول

An Evidence-Based Review on Wound Healing Herbal Remedies From Reports of Traditional Persian Medicine

Ayda Hosseinkhani, PharmD, PhD, Maryam Falahatzadeh, PharmD student, […], and Mohammad M. Zarshenas, PharmD, PhD zarm@sums.ac.ir

Abstract

Research on wound healing agents is a developing area in biomedical sciences. Traditional Persian medicine is one of holistic systems of medicine providing valuable information on natural remedies. To collect the evidences for wound-healing medicaments from traditional Persian medicine sources, 5 main pharmaceutical manuscripts in addition to related contemporary reports from Scopus, PubMed, and ScienceDirect were studied. The underlying mechanisms were also saved and discussed. Totally, 65 herbs used in traditional Persian medicine for their wound healing properties was identified. Related anti-inflammatory, antioxidant, antimicrobial, and wound-healing activities of those remedies were studied. Forty remedies had at least one of those properties and 10 of the filtered plants possessed all effects. The medicinal plants used in wound healing treatment in traditional Persian medicine could be a good topic for further in vivo and clinical research. This might lead to development of effective products for wound treatment.

مقاله دوم

The effect of berberine supplementation on lipid profile and obesity indices: An umbrella review of meta-analysis

Zeynab Kavyani a b 1 , Erfan shahhosseini c 1 , Amir Hossein Moridpour a , Maryam Falahatzadeh d , Mahdi Vajdi e , Vali Musazadeh a b , Gholamreza Askari f

Abstract

Background

Several meta-analyses reported berberine supplementation improves lipid profile and obesity indices, but findings remain conflicting.

Aim of the review

Therefore, we carried out an umbrella review of meta-analysis in order to examine whether berberine supplementation on lipid profile and obesity indices.

Methods

A systematic search was conducted on PubMed, Scopus, Embase, Web of Science, and Google Scholar up to December 2022.

Results

Berberine supplementation was effective in reducing low-density lipoprotein cholesterol (LDL-C) (ES_SMD: −0.56 mg/dL; 95% CI: −0.74 to −0.38, p < 0.001), total cholesterol (TC) (ES_SMD: −0.57 mg/dL, 95% CI: −0.69 to −0.44, p < 0.001), triglyceride (TG) (ES_SMD: −0.47 mg/dL; 95% CI: −0.56 to −0.37, p < 0.001) according to SMD analysis. In addition, berberine significantly increased high-density lipoprotein cholesterol (HDL-C) (ES_SMD: 0.14 mg/dL; 95% CI: 0.08–0.20, p < 0.001) according to SMD analysis. Also, the findings showed that berberine resulted in a significant decrease in waist circumference (WC) (ES _WMD: −1.30 cm; 95% CI: −1.91 to −0.69, p < 0.001), but not in body weight (ES_WMD: −0.86 kg; 95% CI: −2.12 to 0.41), body mass index (BMI) (ES_WMD: −0.57 kg/m²; 95% CI: −1.21 to 0.06, p = 0.078, and ES_SMD: −0.28 kg/m²; 95% CI: −070 to 0.14, p = 0.186), and waist-to-height ratio (WHR) levels (ES_SMD: −0.40; 95% CI: −1.26 to 0.47, p = 0.369).

Conclusion

The results of our study revealed that the supplementation of berberine could be effective in improving WC, and lipid profile, although the impact of this supplement on obesity indices needs further investigation.

مقاله سوم

Effects of Nigella sativa supplementation on lipid profiles in adults: An updated systematic review and meta-analysis of randomized controlled trials

Mahsa Rounagh a 1 , Vali Musazadeh b 1 , Ali Hosseininejad-Mohebati c , Maryam Falahatzadeh d , Zeynab Kavyani g , Reza Bijan Rostami e , Mahdi Vajdi f

Summary

Background and aim

Several experiments have suggested that Nigella sativa (N. sativa) supplementation may have a beneficial effect on the lipid profile. However, the results from these trials have been inconclusive. Therefore, this study aimed to explore the impact of N. sativa supplementation on the lipid profile of adult participants.

Methods

We searched Scopus, Web of Science, PubMed, Cochrane, and Web of Science databases until December 2022. Random effects models were used, and pooled data were determined as standardized mean differences with a 95% confidence interval.

Results

The findings of 34 studies with 2278 participants revealed that N. sativa supplementation significantly reduced total cholesterol (TC) (SMD: −1.78; 95% CI: −2.20, −1.37, p < 0.001), triglycerides (TG) (SMD: −1.2725; 95% CI: −1.67, −0.83, p < 0.001), and low-density lipoprotein cholesterol (LDL-C) (SMD: −2.45; 95% CI: −3.06, −1.85; p < 0.001) compared to control groups. However, a significant increase was found in high-density lipoprotein cholesterol (HDL-C) (SMD: 0.79; 95% CI: 0.38, 1.20, p < 0.001).

Conclusion

N. sativa has improved effects on TG, LDL-C, TC, and HDL-C levels. Overall, N. sativa may be suggested as an adjuvant anti-hyperlipidemic agent.

مقاله چهارم

The status of Iranian hospital pharmacies according to age-friendly pharmacies criteria

Bastani, Peivand; Marzaleh, Milad Ahmadi1; Dehghani, Mina1; Falahatzadeh, Maryam2; Rahmati, Elahe1; Tahernezhad, Ali3

Abstract

Due to the increasing elderly population and the subsequent increase in their need for medication and more referrals to the pharmacy, this study was conducted to investigate the Iranian hospital pharmacies in terms of age-friendliness criteria. This was a cross-sectional study conducted in 2017. The study population included 3 metropolitan hospital pharmacies selected through clustered sampling, and all their 67 pharmacies were included by census. Data collection tool was a reliable researcher-made checklist (t = 0.85, α = 0.9) Data analysis was performed using Kruskal–Wallis test and Mann–Whitney test through SPSS version 24. The results in these three cities showed that only two pharmacies were in a high level of age-friendly. The relationship between type of pharmacy and the final score of age-friendly situation in these cities showed no significant relationship. There was no significant relationship among the average of the final score of the age-friendly situation in three studied cities. Due to the increasing elderly population and the aging society, readiness of Iranian hospital pharmacies to provide services to the elderly will be one of the most challenging issues in the long term. With proper legislation and policies on health-care systems, especially pharmacies, physical and psychological problems in elderly can be reduced in the future. Furthermore, with advancing toward age-friendly pharmacies, the community can be empower and become ready encountering elderly problems.

مقاله پنجم

The effect of Nigella sativa supplementation on glycemic status in adults: An updated systematic review and meta-analysis of randomized controlled trials

Shabnam Shirvani a 1 , Maryam Falahatzadeh b 1 , Elham Oveili c , Mehrdad Jamali d , Pedram Pam d , Maryam Parang e , Mehrnaz Shakarami f

Abstract

This systematic review and meta-analysis of randomized controlled trials (RCTs) sought to evaluate the effects of Nigella sativa (N. sativa) consumption on glycemic index in adults. A systematic literature search up to December 2023 was completed in PubMed, Scopus, and Web of Science, to identify eligible RCTs. Random effects models were assessed based on the heterogeneity tests, and pooled data were determined as weighted mean differences with a 95 % confidence interval. Finally, a total of 30 studies were found to be eligible for this meta-analysis. The pooled results using random effects model indicated that N. sativa supplementation significantly reduced FBS (SMD: −1.71; 95 % CI: −2.11, −1.31, p <0.001; I²= 92.7 %, p-heterogeneity <0.001) and HA1c levels (SMD: −2.16; 95 % CI: –3.04, −1.29, p <0.001; I²= 95.7 %, p-heterogeneity <0.001) but not effect on insulin (SMD = 0.48; 95 % CI: −0.53, 1.48, P = 0.353; I²= 96.1 %, p-heterogeneity <0.001), and HOMA-IR (SMD: −0.56; 95 % CI: −1.47, 0.35, p=0.229; I²= 95.0 %, p-heterogeneity <0.001).Overall, the evidence supports the consumption of N. sativa to reduce FBS and HA1c levels. Additional research, featuring extended durations and robust study designs, is necessary to determine the ideal dosage and duration of N. sativa supplementation for achieving a positive impact on glycemic markers.

مقاله ششم

Effect of curcumin supplementation on symptoms of anxiety: A systematic review and meta-analysis of randomized controlled trials

Soroor Fathi a , Soheil Agharloo a , Maryam Falahatzadeh b , Sara Bahraminavid c , Ali Homayooni d , Amir Hossein Faghfouri e , Daniel Shafiei f , Seyyed-Ghavam Shafagh g

Summary

Background and aim

Curcumin is a polyphenolic natural compound that has been used to treat various ailments such as symptoms of anxiety. However, the findings of studies regarding the anti-anxiety properties of curcumin are controversial. This review aims to evaluate if there are clinical benefits of curcumin in patients with symptoms of anxiety.

Methods

PubMed, Embase, Web of Science, and the Cochrane Library were retrieved to collect randomized controlled trials (RCTs) from the database inception to August 16, 2023. The random-effects model was used to estimate the standard mean difference (SMD).

Results

A total of eight RCTs involving 567 participants were included in the analysis. A pooled analysis showed a significant effect of curcumin on anxiety symptoms (SMD: −1.56; 95% CI: −2.48, −0.64, p < 0.001; I² = 95.6%, p-heterogeneity< 0.001).

Conclusion

Present meta-analysis demonstrated that curcumin intake might contribute to alleviation of anxiety disorder. Due to the limited number of studies included, it is necessary to conduct more high-quality studies to confirm the clinical efficacy of curcumin.

مقاله هفتم

From tradition to science: Possible mechanisms of ghee in supporting bone and joint health

Maryam Falahatzadeh a , Kianoosh Najafi b , Kaveh Bashti c

Abstract

Ghee, a traditional form of clarified butter, has been used for centuries in Ayurvedic medicine for its numerous health benefits. Recent scientific studies have begun to elucidate the molecular mechanisms by which ghee may support bone and joint health. This review explores the bioactive components of ghee, including short-chain fatty acids (SCFAs), medium-chain fatty acids (MCFAs), and fat-soluble vitamins (A, D, E, K2), and their potential therapeutic effects on bone density, joint lubrication, and inflammation. SCFAs in ghee can potentially improve joint lubrication and reduce inflammation. MCFAs and conjugated linoleic acid (CLA) exhibit anti-inflammatory properties, modulating cytokine production and oxidative stress pathways. Vitamins D and K2 in ghee can play potentially crucial roles in calcium metabolism and bone mineralization, while vitamin A supports immune regulation and cartilage health. This review integrates traditional knowledge with contemporary scientific research, highlighting the potential of ghee as a complementary therapy for conditions such as osteoporosis and arthritis. By understanding the molecular mechanisms involved, future studies can focus on this field to shed a light on different effects of ghee on bone and joint health.

مقاله هشتم

The Effect of Glucomannan Supplementation on Lipid Profile in Adults

Authors: Vali Musazadeh, Rogheye Yaraee Rostami, Amir Hossein Moridpour, Zahra Bokaii Hosseini, Omid Nikpayam, Maryam Falahatzadeh & Amir Hossein Faghfouri

688 Accesses | 5 Altmetric | 1 Mention

Abstract

Background: Glucomannan has been studied for various health benefits, but its effects on lipid profile in adults are not well understood. This meta-analysis aims to evaluate the impact of glucomannan supplementation on serum/plasma levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), Apo B1, Apo A1, APO-B/ A1 ratio, and LDL-C/ HDL-C in adults.

Methods: A comprehensive search was conducted across Scopus, PubMed, Embase, and Web of Science from inception to June 2024 to identify randomized controlled trials (RCTs) assessing glucomannan supplementation on lipid profile in adults. Data were extracted and analyzed using random effects model to determine the standardized mean differences (SMDs) and 95% confidence intervals (CIs) for each biomarker.

Results: Glucomannan supplementation significantly decreased TC (SMD: -3.299; 95% CI: -4.955, -1.664, P < 0.001; I 2 = 95.41%, P-heterogeneity < 0.001), LDL-C (SMD: -2.993; 95% CI: -4.958, -1.028; P = 0.006; I 2 = 95.49%, P-heterogeneity < 0.001), and Apo B1 (SMD: -2.2; 95% CI: -3.58, -0.82; P = 0.01). However, glucomannan did not alter the levels of TG (SMD: -0.119; 95% CI: -1.076, 0.837, P = 0.789; I 2 = 91.63%, P-heterogeneity < 0.001), Apo A1 (SMD: -0.48; 95% CI: -6.27, 5.32; P = 0.76), APO-B/ A1 ratio (SMD: -1.15; 95% CI: -2.91, 0.61; P = 0.11), and LDL-C/ HDL-C ratio (SMD: -2.2; 95% CI: -7.28, 2.87; P = 0.2).

Conclusions: Glucomannan supplementation has a beneficial effect on the level of TC and LDL-C.

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مقاله نهم

از سنت تا علم: مکانیسم‌های ممکن کره گی در حمایت از سلامت استخوان و مفاصل

نویسنده: دکتر مریم فلاحت‌زاده

ژورنال: Prostaglandins and Other Lipid Mediators

چکیده

زمینه: کره گی به طور سنتی به دلیل فواید سلامتی آن مورد استفاده قرار گرفته است، اما نقش آن در سلامت استخوان و مفاصل هنوز تحت بررسی علمی قرار دارد. این مقاله مکانیسم‌های بیولوژیکی مختلفی را که از طریق آن‌ها کره گی ممکن است به حمایت از استخوان و مفاصل کمک کند، بررسی می‌کند.

روش‌ها: این مطالعه مقالات علمی و مطالعات بالینی موجود را که تأثیر کره گی بر واکنش‌های التهابی، جذب مواد مغذی و فعالیت آنزیمی مرتبط با سلامت استخوان را ارزیابی می‌کنند، بررسی می‌کند.

نتایج: یافته‌ها نشان می‌دهند که کره گی دارای خواص ضد التهابی است که به کاهش التهاب مفاصل کمک می‌کند. علاوه بر این، جذب مواد مغذی را تقویت کرده و از ساختار و عملکرد استخوان‌ها حمایت می‌کند. این مطالعه همچنین اثرات ترمیمی کره گی بر آسیب‌های بافتی را برجسته می‌کند.

نتیجه‌گیری: مصرف کره گی ممکن است مزایای قابل توجهی برای سلامت استخوان و مفاصل داشته باشد، از جمله کاهش التهاب و بهبود دسترسی زیستی مواد مغذی.

Abstract

Background: Ghee has been traditionally used for its health benefits, but its role in bone and joint health is still under scientific investigation. This article explores the various biological mechanisms by which ghee may contribute to bone and joint support.

Methods: The study reviews existing literature and clinical studies evaluating the impact of ghee on inflammatory responses, nutrient absorption, and enzymatic activity related to bone health.

Results: The findings suggest that ghee possesses anti-inflammatory properties that help reduce joint inflammation. Additionally, it enhances nutrient absorption, supporting bone structure and function. The study also highlights ghee’s reparative effects on tissue damage.

Conclusions: Ghee supplementation may offer significant benefits for bone and joint health by reducing inflammation and improving nutrient bioavailability.

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